Design, synthesis, and biological evaluation of novel N 4 -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

Design, synthesis, and biological evaluation of novel N 4 -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

Abstract Background Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibition dihydrofolate reductase (DHFR) is considered as one of the most pro...

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Bibliographic Details
Main Authors: Essam M. Hussein, Munirah M. Al-Rooqi, Shimaa M. Abd El-Galil, Saleh A. Ahmed
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Chemistry
Subjects:
Sulfonamide
Anticancer
Antimicrobial
Acetamides
Molecular docking
Structure–activity relationship (SAR)
Online Access:http://link.springer.com/article/10.1186/s13065-019-0603-x

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http://link.springer.com/article/10.1186/s13065-019-0603-x

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