Molecular structure of human KATP in complex with ATP and ADP

Molecular structure of human KATP in complex with ATP and ADP

In many excitable cells, KATP channels respond to intracellular adenosine nucleotides: ATP inhibits while ADP activates. We present two structures of the human pancreatic KATP channel, containing the ABC transporter SUR1 and the inward-rectifier K+ channel Kir6.2, in the presence of Mg2+ and nucleot...

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Bibliographic Details
Main Authors:	Kenneth Pak Kin Lee, Jue Chen, Roderick MacKinnon
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-12-01
Series:	eLife
Subjects:	cryo-EM KATP ATP ADP SUR1 Kir6.2
Online Access:	https://elifesciences.org/articles/32481

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