Mechanism of MicroRNA-146a/Notch2 Signaling Regulating IL-6 in Graves Ophthalmopathy

Mechanism of MicroRNA-146a/Notch2 Signaling Regulating IL-6 in Graves Ophthalmopathy

Background/Aims: We intended to investigate the significance of microRNA-146a, Notch2 and IL-6 on Graves ophthalmopathy (GO) and the relationships among them. Methods: About 27 GO patients were incorporated in this study, including 13 patients with inactive GO and14 patients with active GO. Another...

Full description

Bibliographic Details
Main Authors:	Ning Wang, Feng-E Chen, Zi-Wen Long
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2017-03-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Graves ophthalmopathy Notch2 MicroRNA-146a IL-6 qRT-PCR Orbital Fibroblast reporter gene
Online Access:	http://www.karger.com/Article/FullText/464430

Similar Items

Integrative Analysis of Proteomics and DNA Methylation in Orbital Fibroblasts From Graves’ Ophthalmopathy
by: Sita Virakul, et al.
Published: (2021-02-01)

Graves' ophthalmopathy: interdisciplinary approach
Published: (2010-12-01)

Morphofunctional characteristics and immunological regulation of the orbital fibroblasts function in endocrine ophthalmopathy
by: Elizaveta S. Taskina, et al.
Published: (2019-04-01)

Update on pathogenesis and immunology of Graves’ ophthalmopathy
by: Larysa Krajewska-Węglewicz, et al.
Published: (2018-12-01)

Orbital lymphoma mimicking Graves’ ophthalmopathy: a case report
by: Wolyniak Barbara, et al.
Published: (2011-12-01)

Clinical efficacy of orbital decompression in patients with Graves ophthalmopathy
by: Shao-Zhu Hu, et al.
Published: (2017-10-01)

Rituximab therapy in steroid-resistant severe hypothyroid Grave′s ophthalmopathy
by: Aditi Pandit, et al.
Published: (2013-01-01)

Clinical outcomes of radiotherapy as initial local therapy for Graves’ ophthalmopathy and predictors of the need for post-radiotherapy decompressive surgery
by: Prabhu Roshan S, et al.
Published: (2012-06-01)

Practical Guidelines Management of Graves Ophthalmopathy
by: Imam Subekti, et al.
Published: (2019-10-01)

Graves’ Ophthalmopathy Misdiagnosed as Relapsing Conjunctivitis
by: Irini P. Chatziralli, et al.
Published: (2010-09-01)

Clinical evaluation of Graves ophthalmopathy
by: Janićijević-Petrović Mirjana A., et al.
Published: (2012-01-01)

Graves’ ophthalmopathy – thyroid eye disease
by: Dagna Siedlecka, et al.
Published: (2019-08-01)

Use of Rituximab After Orbital Decompression Surgery in Two Grave’s Ophthalmopathy Patients Progressing to Optic Neuropathy
by: Benping Zhang, et al.
Published: (2020-10-01)

Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts–a possible explanation of the link between smoking and Graves’ ophthalmopathy
by: Chiaw Ling Chng, et al.
Published: (2014-06-01)

Orbital decompression surgery for the treatment of Graves' ophthalmopathy: comparison of different techniques and long-term results
by: Mehmet Ozgur Cubuk, et al.
Published: (2018-08-01)

Treatment of ophthalmopathy in the course of Graves’ disease
by: Magdalena Woźniak, et al.
Published: (2019-09-01)

Prevalence of Graves′ ophthalmopathy in patients with Graves′ disease presenting to a referral centre in north India
by: Sagili Vijaya Bhaskar Reddy, et al.
Published: (2014-01-01)

Interpretation of management guidelines for Graves Ophthalmopathy in 2019
by: Yi Shao, et al.
Published: (2021-08-01)

Comparative evaluation of oculometric variables in graves' ophthalmopathy
by: Hélio Amante Miot, et al.
Published: (2009-01-01)

Notch pathway connections in primary leukaemia samples of limited size
by: Luka Horvat, et al.
Published: (2018-09-01)

Assessing quality of life in Taiwanese patients with Graves' ophthalmopathy
by: I-Chan Lin, et al.
Published: (2015-11-01)

Extraocular muscle repositioning as the last therapeutic option for a patient with a severe course of Graves’ Ophthalmopathy: a case report
by: Andrea Rau, et al.
Published: (2018-02-01)

Clinical efficacy of Glucocorticoids, Cyclophosphamide and Octreotide in the treatment of Graves' ophthalmopathy
by: Lu Yang, et al.
Published: (2021-02-01)

Research advances of orbital fibroblasts and thyroid associated ophthalmopathy
by: Jia-Ling Dai, et al.
Published: (2015-06-01)

Graves Ophthalmopathy: Comparison of Clinical Appearance, Thyroid Hormones, and TSH Receptor Antibody Profiles
by: Imam Subekti
Published: (2018-05-01)

Prolapso de gordura orbitária e oftalmopatia de Graves Orbital fat prolapse and Graves' ophthalmopathy
by: Kim-Ir-Sen Santos Teixeira, et al.
Published: (2009-04-01)

Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves’ ophthalmopathy treated with retro-orbital irradiation
by: Lee Victor HF, et al.
Published: (2012-11-01)

Ocular surface changes in Graves’ ophthalmopathy
by: Rou Sun, et al.
Published: (2021-04-01)

Clinical outcomes of graves’ ophthalmopathy treated with intensity modulated radiation therapy
by: Yong-Jiang Li, et al.
Published: (2017-11-01)

Research progress in the selection of surgical methods and complications of orbital decompression in the treatment of Graves ophthalmopathy
by: He Xu, et al.
Published: (2021-09-01)

Investigation of the Correlation between Graves’ Ophthalmopathy and CTLA4 Gene Polymorphism
by: Ding-Ping Chen, et al.
Published: (2019-11-01)

Cytokines as Targets of Novel Therapies for Graves’ Ophthalmopathy
by: Poupak Fallahi, et al.
Published: (2021-04-01)

Th1/Th2 Cytokines in Patients with Graves' Disease with or without Ophthalmopathy
by: Fatemeh Esfahanian, et al.
Published: (2013-06-01)

Clinical course of thyroid function and thyroid associated-ophthalmopathy in patients with euthyroid Graves’ disease
by: Suzuki N, et al.
Published: (2018-04-01)

MiR-146a rs2910164 G > C polymorphism modulates Notch-1/IL-6 signaling during infection: a possible risk factor for Crohn’s disease
by: Esra’a Keewan, et al.
Published: (2020-10-01)

Etanercept in the treatment of Graves’ ophthalmopathy with primary hypothyroidism and rheumatoid arthritis
by: Olivera Boskovic, et al.
Published: (2020-01-01)

Corticosteroids in Moderate-To-Severe Graves’ Ophthalmopathy: Oral or Intravenous Therapy?
by: Laura Penta, et al.
Published: (2019-01-01)

Age Influences the Severity of Graves' Ophthalmopathy
by: Muh-Chiou Lin, et al.
Published: (2008-06-01)

Thymic stromal lymphopoietin gene promoter polymorphisms and expression levels in Graves’ disease and Graves’ ophthalmopathy
by: Tsai Kun-Hsi, et al.
Published: (2012-11-01)

The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy
by: Zhen-Mao Wang, et al.
Published: (2019-07-01)