Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma

Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma

Abstract Background The knowledge about specific mechanisms generating TP53 dysfunction in diffuse large B-cell lymphoma is limited. The aim of the current study was to comprehensively explore TP53 gene variability resulting from somatic mutations, promoter methylation, and allelic imbalance in tumo...

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Bibliographic Details
Main Authors: Elena N. Voropaeva, Tatyana I. Pospelova, Mikhail I. Voevoda, Vladimir N. Maksimov, Yuriy L. Orlov, Olga B. Seregina
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Medical Genomics
Subjects:
TP53 gene
Diffuse large B-cell lymphoma
Methylation
Allelic imbalance
Intron mutations
Sequencing
Online Access:http://link.springer.com/article/10.1186/s12920-019-0484-9

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