Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis

Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis

Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellul...

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Main Authors: Simona L. Schlereth, Nasrin Refaian, Sandra Iden, Claus Cursiefen, Ludwig M. Heindl
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/639058
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spelling doaj-ea28bfa1c4c64a9588a79c98209999712020-11-24T20:43:47ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/639058639058Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer MetastasisSimona L. Schlereth0Nasrin Refaian1Sandra Iden2Claus Cursiefen3Ludwig M. Heindl4Department of Ophthalmology, University of Cologne, Kerpener Straße 62, 50937 Cologne, GermanyDepartment of Ophthalmology, University of Cologne, Kerpener Straße 62, 50937 Cologne, GermanyCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne, GermanyDepartment of Ophthalmology, University of Cologne, Kerpener Straße 62, 50937 Cologne, GermanyDepartment of Ophthalmology, University of Cologne, Kerpener Straße 62, 50937 Cologne, GermanyLymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellular matrix as well as cytokines and growth factors are involved in the process of lymphangiogenesis and metastasis. The cellular and noncellular components influence each other and can be influenced by the tumor cells. The knowledge about mechanisms behind lymphangiogenesis in the tumor microenvironmental crosstalk is growing and offers starting points for new therapeutic approaches.http://dx.doi.org/10.1155/2014/639058
collection DOAJ
language English
format Article
sources DOAJ
author Simona L. Schlereth
Nasrin Refaian
Sandra Iden
Claus Cursiefen
Ludwig M. Heindl
spellingShingle Simona L. Schlereth
Nasrin Refaian
Sandra Iden
Claus Cursiefen
Ludwig M. Heindl
Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis
BioMed Research International
author_facet Simona L. Schlereth
Nasrin Refaian
Sandra Iden
Claus Cursiefen
Ludwig M. Heindl
author_sort Simona L. Schlereth
title Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis
title_short Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis
title_full Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis
title_fullStr Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis
title_full_unstemmed Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis
title_sort impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellular matrix as well as cytokines and growth factors are involved in the process of lymphangiogenesis and metastasis. The cellular and noncellular components influence each other and can be influenced by the tumor cells. The knowledge about mechanisms behind lymphangiogenesis in the tumor microenvironmental crosstalk is growing and offers starting points for new therapeutic approaches.
url http://dx.doi.org/10.1155/2014/639058
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AT nasrinrefaian impactoftheprolymphangiogeniccrosstalkinthetumormicroenvironmentonlymphaticcancermetastasis
AT sandraiden impactoftheprolymphangiogeniccrosstalkinthetumormicroenvironmentonlymphaticcancermetastasis
AT clauscursiefen impactoftheprolymphangiogeniccrosstalkinthetumormicroenvironmentonlymphaticcancermetastasis
AT ludwigmheindl impactoftheprolymphangiogeniccrosstalkinthetumormicroenvironmentonlymphaticcancermetastasis
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