3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells

3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells

Obesity is one of the world's largest health problems, and 3-N-butylphthalide (NBP), a bioactive compound in celery, has been used in dieting and weight management programs. In this study, NBP prevented high-fat-diet-induced weight gain, reduced the food efficiency ratio, altered the blood bioc...

Full description

Bibliographic Details
Main Authors: Kang-Yun Lu, Shinn-Zong Lin, Kingsley Theras Primus Dass, Wei-Ju Lin, Shih-Ping Liu, Horng-Jyh Harn
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Celery (Apium graveolens)
Obesity
Metabolism
Thermogenesis
Anti-inflammation
Traditional Chinese Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004698
id doaj-ea23c36902f84eff99e43c4a00aa1a73
record_format Article
spelling doaj-ea23c36902f84eff99e43c4a00aa1a732021-06-03T04:55:23ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-07-011391116873-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cellsKang-Yun Lu0Shinn-Zong Lin1Kingsley Theras Primus Dass2Wei-Ju Lin3Shih-Ping Liu4Horng-Jyh Harn5Buddhist Tzu Chi Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan; Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, TaiwanBuddhist Tzu Chi Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan; Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien 970, TaiwanDepartment of Medical Research, Hualien Tzu Chi Hospital, Hualien 970, TaiwanBuddhist Tzu Chi Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien 970, TaiwanPh. D. Program for Aging, College of Medicine, China Medical University, Taichung 404, Taiwan; Center for Translational Medicine, China Medical University Hospital, Taichung 404, Taiwan; Department of Social Work, Asia University, Taichung 404, Taiwan; Corresponding author at: Ph. D. Program for Aging, College of Medicine, China Medical University, Taichung 404, Taiwan.Buddhist Tzu Chi Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan; Department of Pathology, Hualien Tzu Chi Hospital and Tzu Chi University, Hualien 970, Taiwan; Corresponding author at: Buddhist Tzu Chi Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.Obesity is one of the world's largest health problems, and 3-N-butylphthalide (NBP), a bioactive compound in celery, has been used in dieting and weight management programs. In this study, NBP prevented high-fat-diet-induced weight gain, reduced the food efficiency ratio, altered the blood biochemical profile, and reduced the obesity-related index. NBP reduced adiposity, white fat depots, liver weight, and hepatic steatosis in obese mice. NBP ameliorated the diabetic state by decreasing glucose levels and improving glucose and insulin tolerance. NBP increased uncoupling protein-1 expression in white adipose tissue and upregulated thermogenesis by enhancing mitochondrial respiration. NBP inhibited white adipocyte development by prohibiting lipid accumulation in human adipose-derived stem cells. NBP increased free fatty acid uptake and the oxygen consumption rate in beige adipocytes. Our results suggest that NBP could be used as functional natural supplement against obesity and its associated disorders.http://www.sciencedirect.com/science/article/pii/S0753332221004698Celery (Apium graveolens)ObesityMetabolismThermogenesisAnti-inflammationTraditional Chinese Medicine
collection DOAJ
language English
format Article
sources DOAJ
author Kang-Yun Lu
Shinn-Zong Lin
Kingsley Theras Primus Dass
Wei-Ju Lin
Shih-Ping Liu
Horng-Jyh Harn
spellingShingle Kang-Yun Lu
Shinn-Zong Lin
Kingsley Theras Primus Dass
Wei-Ju Lin
Shih-Ping Liu
Horng-Jyh Harn
3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
Biomedicine & Pharmacotherapy
Celery (Apium graveolens)
Obesity
Metabolism
Thermogenesis
Anti-inflammation
Traditional Chinese Medicine
author_facet Kang-Yun Lu
Shinn-Zong Lin
Kingsley Theras Primus Dass
Wei-Ju Lin
Shih-Ping Liu
Horng-Jyh Harn
author_sort Kang-Yun Lu
title 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
title_short 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
title_full 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
title_fullStr 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
title_full_unstemmed 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
title_sort 3-n-butylphthalide protects against high-fat-diet-induced obesity in c57bl/6 mice and increases metabolism in lipid-accumulating cells
publisher Elsevier
series Biomedicine & Pharmacotherapy
issn 0753-3322
publishDate 2021-07-01
description Obesity is one of the world's largest health problems, and 3-N-butylphthalide (NBP), a bioactive compound in celery, has been used in dieting and weight management programs. In this study, NBP prevented high-fat-diet-induced weight gain, reduced the food efficiency ratio, altered the blood biochemical profile, and reduced the obesity-related index. NBP reduced adiposity, white fat depots, liver weight, and hepatic steatosis in obese mice. NBP ameliorated the diabetic state by decreasing glucose levels and improving glucose and insulin tolerance. NBP increased uncoupling protein-1 expression in white adipose tissue and upregulated thermogenesis by enhancing mitochondrial respiration. NBP inhibited white adipocyte development by prohibiting lipid accumulation in human adipose-derived stem cells. NBP increased free fatty acid uptake and the oxygen consumption rate in beige adipocytes. Our results suggest that NBP could be used as functional natural supplement against obesity and its associated disorders.
topic Celery (Apium graveolens)
Obesity
Metabolism
Thermogenesis
Anti-inflammation
Traditional Chinese Medicine
url http://www.sciencedirect.com/science/article/pii/S0753332221004698
work_keys_str_mv AT kangyunlu 3nbutylphthalideprotectsagainsthighfatdietinducedobesityinc57bl6miceandincreasesmetabolisminlipidaccumulatingcells
AT shinnzonglin 3nbutylphthalideprotectsagainsthighfatdietinducedobesityinc57bl6miceandincreasesmetabolisminlipidaccumulatingcells
AT kingsleytherasprimusdass 3nbutylphthalideprotectsagainsthighfatdietinducedobesityinc57bl6miceandincreasesmetabolisminlipidaccumulatingcells
AT weijulin 3nbutylphthalideprotectsagainsthighfatdietinducedobesityinc57bl6miceandincreasesmetabolisminlipidaccumulatingcells
AT shihpingliu 3nbutylphthalideprotectsagainsthighfatdietinducedobesityinc57bl6miceandincreasesmetabolisminlipidaccumulatingcells
AT horngjyhharn 3nbutylphthalideprotectsagainsthighfatdietinducedobesityinc57bl6miceandincreasesmetabolisminlipidaccumulatingcells
_version_ 1721399897849069568

Similar Items