Physiological response of <it>Pichia pastoris</it> GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes

Physiological response of <it>Pichia pastoris</it> GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes

<p>Abstract</p> <p>Background</p> <p><it>Pichia pastoris</it> is an established eukaryotic host for the production of recombinant proteins. Most often, protein production is under the control of the strong methanol-inducible <it>aox1</it> promote...

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Bibliographic Details
Main Authors: Vanz Ana Leticia, Lünsdorf Heinrich, Adnan Ahmad, Nimtz Manfred, Gurramkonda Chandrasekhar, Khanna Navin, Rinas Ursula
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Microbial Cell Factories
Subjects:
<it>Pichia pastoris</it>
Proteome
<it>Aox1</it> promoter
Carbon metabolism
ER stress
Autophagy
Online Access:http://www.microbialcellfactories.com/content/11/1/103

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