Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study

• Main Authors: Constantin Bălăeţ, Bogdan Ioan Coculescu, Gheorghe Manole, Maria Bălăeţ, Gabi Valeriu Dincă
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2018-01-01
• Series: Journal of Enzyme Inhibition and Medicinal Chemistry
• Subjects: Gamma-glutamyltransferase; inflammation marker; colon polyposis; oxidative stress
• Online Access: http://dx.doi.org/10.1080/14756366.2018.1428802

The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases diagnosed with colon diverticulosis-diverticulitis associated with polyposis at the same intestinal level, identifies the presence of increased circulating concentrations of this enzyme in the serum. Its serum levels are tracked “dynamically” throughout a year after the diagnosis and start of the therapy. The study calls into question the release of the enzyme from the edge of the enterocytes’ brush-like edge, leading to the pathogenic disturbance of regional redox homeostasis. The hypothesis gives the circulating values of GGT predictive value for cellular oxidative stress, as well as for indirectly expressing the glutathione level in cytosol.