Ovarian cancer mouse models: a summary of current models and their limitations
<p>Abstract</p> <p>Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different types of ovarian cancer are needed to understand how epi...
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BMC
2009-09-01
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| Series: | Journal of Ovarian Research |
| Online Access: | http://www.ovarianresearch.com/content/2/1/12 |
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doaj-ea15a68b6a904277a62b8d33f55ff64c2020-11-24T21:11:28ZengBMCJournal of Ovarian Research1757-22152009-09-01211210.1186/1757-2215-2-12Ovarian cancer mouse models: a summary of current models and their limitationsFong Miranda YKakar Sham S<p>Abstract</p> <p>Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different types of ovarian cancer are needed to understand how epithelial ovarian cancer differs from granulosa cell tumors. Many different methods have been used to generate a viable genetic model with limited success. This review focuses on the methods of various investigators and the limitations of each model in establishing a reproducible and inheritable line to study this disease.</p> http://www.ovarianresearch.com/content/2/1/12 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fong Miranda Y Kakar Sham S |
| spellingShingle |
Fong Miranda Y Kakar Sham S Ovarian cancer mouse models: a summary of current models and their limitations Journal of Ovarian Research |
| author_facet |
Fong Miranda Y Kakar Sham S |
| author_sort |
Fong Miranda Y |
| title |
Ovarian cancer mouse models: a summary of current models and their limitations |
| title_short |
Ovarian cancer mouse models: a summary of current models and their limitations |
| title_full |
Ovarian cancer mouse models: a summary of current models and their limitations |
| title_fullStr |
Ovarian cancer mouse models: a summary of current models and their limitations |
| title_full_unstemmed |
Ovarian cancer mouse models: a summary of current models and their limitations |
| title_sort |
ovarian cancer mouse models: a summary of current models and their limitations |
| publisher |
BMC |
| series |
Journal of Ovarian Research |
| issn |
1757-2215 |
| publishDate |
2009-09-01 |
| description |
<p>Abstract</p> <p>Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different types of ovarian cancer are needed to understand how epithelial ovarian cancer differs from granulosa cell tumors. Many different methods have been used to generate a viable genetic model with limited success. This review focuses on the methods of various investigators and the limitations of each model in establishing a reproducible and inheritable line to study this disease.</p> |
| url |
http://www.ovarianresearch.com/content/2/1/12 |
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AT fongmiranday ovariancancermousemodelsasummaryofcurrentmodelsandtheirlimitations AT kakarshams ovariancancermousemodelsasummaryofcurrentmodelsandtheirlimitations |
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