Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats

Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats

Background: Acute renal failure is a dose-limiting factor of cisplatin chemotherapy. Here, we show the protective effect of ozone oxidative preconditioning against cisplatin-induced renal dysfunction in rats. Ozone oxidative preconditioning is a prophylactic approach, which favors the antioxidant–pr...

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Bibliographic Details
Main Authors: Aluet Borrego, Zullyt B. Zamora, Ricardo González, Cheyla Romay, Silvia Menéndez, Frank Hernández, Teresita Montero, Enys Rojas
Format: Article
Language:English
Published: Hindawi Limited 2004-01-01
Series:Mediators of Inflammation
Subjects:
Ozone oxidative preconditioning
Cisplatin-induced nephrotoxicity
Antioxidant defenses
Lipid peroxidation.
Online Access:http://dx.doi.org/10.1080/09629350410001664806
Description
Summary:Background: Acute renal failure is a dose-limiting factor of cisplatin chemotherapy. Here, we show the protective effect of ozone oxidative preconditioning against cisplatin-induced renal dysfunction in rats. Ozone oxidative preconditioning is a prophylactic approach, which favors the antioxidant–pro-oxidant balance for preservation of the cell redox state by increasing antioxidant endogenous systems in various in vivo and in vitro experimental models.
ISSN:0962-9351
1466-1861

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