Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention

Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention

Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. T...

Full description

Bibliographic Details
Main Authors: Charlotte Skinner, Alex J. Thompson, Mark R. Thursz, Julian R. Marchesi, Nikhil Vergis
Format: Article
Language:English
Published: SAGE Publishing 2020-10-01
Series:Therapeutic Advances in Gastroenterology
Online Access:https://doi.org/10.1177/1756284820942616
id doaj-ea0ab47f20d4446b9434b76833815517
record_format Article
spelling doaj-ea0ab47f20d4446b9434b768338155172020-11-25T01:59:37ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482020-10-011310.1177/1756284820942616Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic interventionCharlotte SkinnerAlex J. ThompsonMark R. ThurszJulian R. MarchesiNikhil VergisIncreased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. There are a number of methods available to assess IP and in this review we look at their various advantages and limitations. The knowledge around BT and IP in ArLD is also reviewed, as well as the therapeutic strategies currently in use and in development.https://doi.org/10.1177/1756284820942616
collection DOAJ
language English
format Article
sources DOAJ
author Charlotte Skinner
Alex J. Thompson
Mark R. Thursz
Julian R. Marchesi
Nikhil Vergis
spellingShingle Charlotte Skinner
Alex J. Thompson
Mark R. Thursz
Julian R. Marchesi
Nikhil Vergis
Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
Therapeutic Advances in Gastroenterology
author_facet Charlotte Skinner
Alex J. Thompson
Mark R. Thursz
Julian R. Marchesi
Nikhil Vergis
author_sort Charlotte Skinner
title Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_short Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_full Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_fullStr Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_full_unstemmed Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_sort intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
publisher SAGE Publishing
series Therapeutic Advances in Gastroenterology
issn 1756-2848
publishDate 2020-10-01
description Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. There are a number of methods available to assess IP and in this review we look at their various advantages and limitations. The knowledge around BT and IP in ArLD is also reviewed, as well as the therapeutic strategies currently in use and in development.
url https://doi.org/10.1177/1756284820942616
work_keys_str_mv AT charlotteskinner intestinalpermeabilityandbacterialtranslocationinpatientswithliverdiseasefocusingonalcoholicaetiologymethodsofassessmentandtherapeuticintervention
AT alexjthompson intestinalpermeabilityandbacterialtranslocationinpatientswithliverdiseasefocusingonalcoholicaetiologymethodsofassessmentandtherapeuticintervention
AT markrthursz intestinalpermeabilityandbacterialtranslocationinpatientswithliverdiseasefocusingonalcoholicaetiologymethodsofassessmentandtherapeuticintervention
AT julianrmarchesi intestinalpermeabilityandbacterialtranslocationinpatientswithliverdiseasefocusingonalcoholicaetiologymethodsofassessmentandtherapeuticintervention
AT nikhilvergis intestinalpermeabilityandbacterialtranslocationinpatientswithliverdiseasefocusingonalcoholicaetiologymethodsofassessmentandtherapeuticintervention
_version_ 1724963557061165056

Similar Items