Stress induced experimental colitis

Stress induced experimental colitis

Stress induces chemical changes in the central nervous system which alters the biochemistry and physiology of the digestive tract. The present study determines arachidonic acid oxidation and damage in the colon following stress. Ten rats were stressed by the cold-restraint method; ten were controls....

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Main Authors: T. A. Stein, L. Keegan, L.-J. Auguste, B. Bailey, L. Wise
Format: Article
Language:English
Published: Hindawi Limited 1993-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/S0962935193000353
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spelling doaj-ea039943e0324d1a8eed0da0828d60ad2020-11-24T22:18:50ZengHindawi LimitedMediators of Inflammation0962-93511466-18611993-01-012325325610.1155/S0962935193000353Stress induced experimental colitisT. A. Stein0L. Keegan1L.-J. Auguste2B. Bailey3L. Wise4Department of Surgery, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, 270-05 76th Avenue, New Hyde Park 11042, NY, USADepartment of Surgery, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, 270-05 76th Avenue, New Hyde Park 11042, NY, USADepartment of Surgery, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, 270-05 76th Avenue, New Hyde Park 11042, NY, USADepartment of Surgery, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, 270-05 76th Avenue, New Hyde Park 11042, NY, USADepartment of Surgery, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, 270-05 76th Avenue, New Hyde Park 11042, NY, USAStress induces chemical changes in the central nervous system which alters the biochemistry and physiology of the digestive tract. The present study determines arachidonic acid oxidation and damage in the colon following stress. Ten rats were stressed by the cold-restraint method; ten were controls. Stress induced 0.5 ± 0.7 (S.D.) mucosal erosions whereas controls had none. Subepithelial hemorrhage and erosions occurred only in the proximal two-thirds of the colon. Prostaglandin E2 synthesis was increased after stress compared to the control (381 ± 130 vs. 1610 ± 372 ng/g/min). Leukotriene C4 synthesis also increased after stress (4217 ± 994 vs. 11300 ± 1662 ng/g/min). Synthesis of prostaglandin E2 increased (r = 0.9381) with leukotriene C4. The response of the colon to stress is less severe than that in the stomach and may be related to regional regulation of prostaglandin and leukotriene synthesis.http://dx.doi.org/10.1155/S0962935193000353
collection DOAJ
language English
format Article
sources DOAJ
author T. A. Stein
L. Keegan
L.-J. Auguste
B. Bailey
L. Wise
spellingShingle T. A. Stein
L. Keegan
L.-J. Auguste
B. Bailey
L. Wise
Stress induced experimental colitis
Mediators of Inflammation
author_facet T. A. Stein
L. Keegan
L.-J. Auguste
B. Bailey
L. Wise
author_sort T. A. Stein
title Stress induced experimental colitis
title_short Stress induced experimental colitis
title_full Stress induced experimental colitis
title_fullStr Stress induced experimental colitis
title_full_unstemmed Stress induced experimental colitis
title_sort stress induced experimental colitis
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 1993-01-01
description Stress induces chemical changes in the central nervous system which alters the biochemistry and physiology of the digestive tract. The present study determines arachidonic acid oxidation and damage in the colon following stress. Ten rats were stressed by the cold-restraint method; ten were controls. Stress induced 0.5 ± 0.7 (S.D.) mucosal erosions whereas controls had none. Subepithelial hemorrhage and erosions occurred only in the proximal two-thirds of the colon. Prostaglandin E2 synthesis was increased after stress compared to the control (381 ± 130 vs. 1610 ± 372 ng/g/min). Leukotriene C4 synthesis also increased after stress (4217 ± 994 vs. 11300 ± 1662 ng/g/min). Synthesis of prostaglandin E2 increased (r = 0.9381) with leukotriene C4. The response of the colon to stress is less severe than that in the stomach and may be related to regional regulation of prostaglandin and leukotriene synthesis.
url http://dx.doi.org/10.1155/S0962935193000353
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AT lkeegan stressinducedexperimentalcolitis
AT ljauguste stressinducedexperimentalcolitis
AT bbailey stressinducedexperimentalcolitis
AT lwise stressinducedexperimentalcolitis
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