Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic formation of immunological memory. Statistical analysis of repertoire sequencing data has the potential to decode disease associations from large cohorts with measured phenotypes. However, the repertoire perturb...

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Bibliographic Details
Main Authors: William S DeWitt III, Anajane Smith, Gary Schoch, John A Hansen, Frederick A Matsen IV, Philip Bradley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
adaptive immunity
T cell repertoires
T cell receptor sequencing
Online Access:https://elifesciences.org/articles/38358

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