The Cranial Neural Crest in a Multiomics Era

• Main Authors: Vanessa Chong-Morrison, Tatjana Sauka-Spengler
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-03-01
• Series: Frontiers in Physiology
• Subjects: neural crest; multiomics; gene regulatory network; non-coding; interactome; transcriptome
• Online Access: https://www.frontiersin.org/articles/10.3389/fphys.2021.634440/full

Neural crest ontogeny plays a prominent role in craniofacial development. In this Perspective article, we discuss recent advances to the understanding of mechanisms underlying the cranial neural crest gene regulatory network (cNC-GRN) stemming from omics-based studies. We briefly summarize how parallel considerations of transcriptome, interactome, and epigenome data significantly elaborated the roles of key players derived from pre-omics era studies. Furthermore, the growing cohort of cNC multiomics data revealed contribution of the non-coding genomic landscape. As technological improvements are constantly being developed, we reflect on key questions we are poised to address by taking advantage of the unique perspective a multiomics approach has to offer.