Haplotyping-based preimplantation genetic testing reveals parent-of-origin specific mechanisms of aneuploidy formation

Haplotyping-based preimplantation genetic testing reveals parent-of-origin specific mechanisms of aneuploidy formation

Abstract Chromosome instability is inherent to human IVF embryos, but the full spectrum and developmental fate of chromosome anomalies remain uncharacterized. Using haplotyping-based preimplantation genetic testing for monogenic diseases (PGT-M), we mapped the parental and mechanistic origin of comm...

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Bibliographic Details
Main Authors: Olga Tšuiko, Michiel Vanneste, Cindy Melotte, Jia Ding, Sophie Debrock, Heleen Masset, Maire Peters, Andres Salumets, Anne De Leener, Céline Pirard, Candice Kluyskens, Katleen Hostens, Arne van de Vijver, Karen Peeraer, Ellen Denayer, Joris Robert Vermeesch, Eftychia Dimitriadou
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-021-00246-0

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