SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1Research in context

SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1Research in context

Background: Programmed death-ligand 1 (PD-L1) is a T-cell inhibitory checkpoint molecule that suppresses antitumor immunity. Anti-PD-L1 antibodies have shown remarkable promise in treating tumors, but the patient response rate is low. Therefore, small-molecule checkpoint inhibitors blocking PD-L1 fu...

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Bibliographic Details
Main Authors: Na Zhang, Yueying Dou, Lu Liu, Xin Zhang, Xiaojia Liu, Qingxuan Zeng, Yang Liu, Mingxiao Yin, Xiujun Liu, Hongbin Deng, Danqing Song
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641930060X

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