Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of the large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) is another rare disease with localized amyloid deposits in the tracheobronchial tree...
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doaj-e9da100d459f4f26811a7dfde88ccd382020-12-17T04:48:28ZengElsevierRespiratory Medicine Case Reports2213-00712020-01-0131101158Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)Ju Yeun Song0Bo-Guen Kim1Sungmin Zo2Sujin Park3Joung Ho Han4Hojoong Kim5Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Corresponding author.Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of the large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) is another rare disease with localized amyloid deposits in the tracheobronchial tree. The two diseases rarely coincide, and only a few case reports and series have been reported.A patient with dyspnea was referred to our clinic for suspicion of TBA. Chest computed tomography (CT) scan showed marked thickening of the tracheobronchial wall with calcified endobronchial submucosal nodules. The nodules were resected with a Diode Laser under rigid bronchoscopy, and results from the biopsy showed both osteochondroid metaplasia on microscopy in Hematoxylin and Eosin staining and apple-green birefringence on polarized microscopy in Congo red staining. This is a rare case in which microscopic findings of both TPO and TBA were observed on one slide. These findings suggest that localized TBA could be a cause of TPO.http://www.sciencedirect.com/science/article/pii/S2213007120303713 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ju Yeun Song Bo-Guen Kim Sungmin Zo Sujin Park Joung Ho Han Hojoong Kim |
spellingShingle |
Ju Yeun Song Bo-Guen Kim Sungmin Zo Sujin Park Joung Ho Han Hojoong Kim Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA) Respiratory Medicine Case Reports |
author_facet |
Ju Yeun Song Bo-Guen Kim Sungmin Zo Sujin Park Joung Ho Han Hojoong Kim |
author_sort |
Ju Yeun Song |
title |
Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA) |
title_short |
Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA) |
title_full |
Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA) |
title_fullStr |
Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA) |
title_full_unstemmed |
Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA) |
title_sort |
tracheobronchopathia osteochondroplastica (tpo) associated with tracheobronchial amyloidosis (tba) |
publisher |
Elsevier |
series |
Respiratory Medicine Case Reports |
issn |
2213-0071 |
publishDate |
2020-01-01 |
description |
Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of the large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) is another rare disease with localized amyloid deposits in the tracheobronchial tree. The two diseases rarely coincide, and only a few case reports and series have been reported.A patient with dyspnea was referred to our clinic for suspicion of TBA. Chest computed tomography (CT) scan showed marked thickening of the tracheobronchial wall with calcified endobronchial submucosal nodules. The nodules were resected with a Diode Laser under rigid bronchoscopy, and results from the biopsy showed both osteochondroid metaplasia on microscopy in Hematoxylin and Eosin staining and apple-green birefringence on polarized microscopy in Congo red staining. This is a rare case in which microscopic findings of both TPO and TBA were observed on one slide. These findings suggest that localized TBA could be a cause of TPO. |
url |
http://www.sciencedirect.com/science/article/pii/S2213007120303713 |
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