Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)

Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of the large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) is another rare disease with localized amyloid deposits in the tracheobronchial tree...

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Main Authors: Ju Yeun Song, Bo-Guen Kim, Sungmin Zo, Sujin Park, Joung Ho Han, Hojoong Kim
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Respiratory Medicine Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213007120303713
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spelling doaj-e9da100d459f4f26811a7dfde88ccd382020-12-17T04:48:28ZengElsevierRespiratory Medicine Case Reports2213-00712020-01-0131101158Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)Ju Yeun Song0Bo-Guen Kim1Sungmin Zo2Sujin Park3Joung Ho Han4Hojoong Kim5Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Corresponding author.Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of the large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) is another rare disease with localized amyloid deposits in the tracheobronchial tree. The two diseases rarely coincide, and only a few case reports and series have been reported.A patient with dyspnea was referred to our clinic for suspicion of TBA. Chest computed tomography (CT) scan showed marked thickening of the tracheobronchial wall with calcified endobronchial submucosal nodules. The nodules were resected with a Diode Laser under rigid bronchoscopy, and results from the biopsy showed both osteochondroid metaplasia on microscopy in Hematoxylin and Eosin staining and apple-green birefringence on polarized microscopy in Congo red staining. This is a rare case in which microscopic findings of both TPO and TBA were observed on one slide. These findings suggest that localized TBA could be a cause of TPO.http://www.sciencedirect.com/science/article/pii/S2213007120303713
collection DOAJ
language English
format Article
sources DOAJ
author Ju Yeun Song
Bo-Guen Kim
Sungmin Zo
Sujin Park
Joung Ho Han
Hojoong Kim
spellingShingle Ju Yeun Song
Bo-Guen Kim
Sungmin Zo
Sujin Park
Joung Ho Han
Hojoong Kim
Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
Respiratory Medicine Case Reports
author_facet Ju Yeun Song
Bo-Guen Kim
Sungmin Zo
Sujin Park
Joung Ho Han
Hojoong Kim
author_sort Ju Yeun Song
title Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
title_short Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
title_full Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
title_fullStr Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
title_full_unstemmed Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
title_sort tracheobronchopathia osteochondroplastica (tpo) associated with tracheobronchial amyloidosis (tba)
publisher Elsevier
series Respiratory Medicine Case Reports
issn 2213-0071
publishDate 2020-01-01
description Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of the large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) is another rare disease with localized amyloid deposits in the tracheobronchial tree. The two diseases rarely coincide, and only a few case reports and series have been reported.A patient with dyspnea was referred to our clinic for suspicion of TBA. Chest computed tomography (CT) scan showed marked thickening of the tracheobronchial wall with calcified endobronchial submucosal nodules. The nodules were resected with a Diode Laser under rigid bronchoscopy, and results from the biopsy showed both osteochondroid metaplasia on microscopy in Hematoxylin and Eosin staining and apple-green birefringence on polarized microscopy in Congo red staining. This is a rare case in which microscopic findings of both TPO and TBA were observed on one slide. These findings suggest that localized TBA could be a cause of TPO.
url http://www.sciencedirect.com/science/article/pii/S2213007120303713
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