Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell lines.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24034-7 |
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doaj-e9d685fa483d413282b0592f44b963bf2021-06-27T11:11:47ZengNature Publishing GroupNature Communications2041-17232021-06-0112111810.1038/s41467-021-24034-7Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entryAmit Kulkarni0Tiago Ferreira1Clemens Bretscher2Annabel Grewenig3Nazim El-Andaloussi4Serena Bonifati5Tiina Marttila6Valérie Palissot7Jubayer A. Hossain8Francisco Azuaje9Hrvoje Miletic10Lars A. R. Ystaas11Anna Golebiewska12Simone P. Niclou13Ralf Roeth14Beate Niesler15Amélie Weiss16Laurent Brino17Antonio Marchini18Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research CenterLaboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research CenterLaboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research CenterLaboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research CenterLaboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research CenterLaboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research CenterLaboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research CenterLaboratory of Oncolytic Virus Immuno-Therapeutics, Luxembourg Institute of HealthLaboratory of Oncolytic Virus Immuno-Therapeutics, Luxembourg Institute of HealthQuantitative Biology Unit, Luxembourg Institute of HealthDepartment of Biomedicine, University of BergenDepartment of Biomedicine, University of BergenNorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of HealthNorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of HealthnCounter Core Facility, Institute of Human Genetics, University of HeidelbergnCounter Core Facility, Institute of Human Genetics, University of HeidelbergInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research CenterRat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell lines.https://doi.org/10.1038/s41467-021-24034-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Amit Kulkarni Tiago Ferreira Clemens Bretscher Annabel Grewenig Nazim El-Andaloussi Serena Bonifati Tiina Marttila Valérie Palissot Jubayer A. Hossain Francisco Azuaje Hrvoje Miletic Lars A. R. Ystaas Anna Golebiewska Simone P. Niclou Ralf Roeth Beate Niesler Amélie Weiss Laurent Brino Antonio Marchini |
| spellingShingle |
Amit Kulkarni Tiago Ferreira Clemens Bretscher Annabel Grewenig Nazim El-Andaloussi Serena Bonifati Tiina Marttila Valérie Palissot Jubayer A. Hossain Francisco Azuaje Hrvoje Miletic Lars A. R. Ystaas Anna Golebiewska Simone P. Niclou Ralf Roeth Beate Niesler Amélie Weiss Laurent Brino Antonio Marchini Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry Nature Communications |
| author_facet |
Amit Kulkarni Tiago Ferreira Clemens Bretscher Annabel Grewenig Nazim El-Andaloussi Serena Bonifati Tiina Marttila Valérie Palissot Jubayer A. Hossain Francisco Azuaje Hrvoje Miletic Lars A. R. Ystaas Anna Golebiewska Simone P. Niclou Ralf Roeth Beate Niesler Amélie Weiss Laurent Brino Antonio Marchini |
| author_sort |
Amit Kulkarni |
| title |
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry |
| title_short |
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry |
| title_full |
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry |
| title_fullStr |
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry |
| title_full_unstemmed |
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry |
| title_sort |
oncolytic h-1 parvovirus binds to sialic acid on laminins for cell attachment and entry |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-06-01 |
| description |
Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell lines. |
| url |
https://doi.org/10.1038/s41467-021-24034-7 |
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