Utilizing in vitro transporter data in IVIVE-PBPK: an overview
In vitro-in vivo extrapolation (IVIVE) integrated in physiologically-based pharmacokinetic (PBPK) models have been increasingly used during drug discovery and development processes to predict human pharmacokinetic (PK) parameters. Drug transporters can influence drug pharmacokinetics and are key asp...
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| Format: | Article |
| Language: | English |
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International Association of Physical Chemists (IAPC)
2017-12-01
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| Series: | ADMET and DMPK |
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| Online Access: | http://pub.iapchem.org/ojs/index.php/admet/article/view/441 |