Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses ex vivo

Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses ex vivo

Because of the potent graft-versus-tumor (GVT) effect, allogeneic stem cell transplantation (alloSCT) can be a curative therapy for hematological malignancies. However, relapse remains the most frequent cause of treatment failure, illustrating the necessity for development of adjuvant post-transplan...

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Bibliographic Details
Main Authors: Soley Thordardottir, Nicolaas Schaap, Elja Louer, Michel G. D. Kester, J. H. Frederik Falkenburg, Joop Jansen, Timothy R. D. Radstake, Willemijn Hobo, Harry Dolstra
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:OncoImmunology
Subjects:
antitumor immunity
dendritic cells
graft-versus-tumor immunity
hematopoietic stem and progenitor cell
mdc
nk cell
pdc
t cell
vaccination
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1285991

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