Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways

Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways

Nitrogen-starved fission yeast cells survive for weeks without dividing. Here, the authors show that some of these surviving cells accumulate mutations in the stress- and mitogen-activated protein kinase pathways and outcompete their parental cells, which provide nutrients for the mutant cells.

Bibliographic Details
Main Authors: Rostyslav Makarenko, Claire Denis, Stefania Francesconi, Serge Gangloff, Benoît Arcangioli
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15880-y
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spelling doaj-e9ad02e770e946138ceeb1a29db9280c2021-05-11T08:43:05ZengNature Publishing GroupNature Communications2041-17232020-04-0111111310.1038/s41467-020-15880-yNitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathwaysRostyslav Makarenko0Claire Denis1Stefania Francesconi2Serge Gangloff3Benoît Arcangioli4Genome Dynamics Unit, Institut Pasteur, UMR3525 CNRSGenome Dynamics Unit, Institut Pasteur, UMR3525 CNRSGenome Dynamics Unit, Institut Pasteur, UMR3525 CNRSGenome Dynamics Unit, Institut Pasteur, UMR3525 CNRSGenome Dynamics Unit, Institut Pasteur, UMR3525 CNRSNitrogen-starved fission yeast cells survive for weeks without dividing. Here, the authors show that some of these surviving cells accumulate mutations in the stress- and mitogen-activated protein kinase pathways and outcompete their parental cells, which provide nutrients for the mutant cells.https://doi.org/10.1038/s41467-020-15880-y
collection DOAJ
language English
format Article
sources DOAJ
author Rostyslav Makarenko
Claire Denis
Stefania Francesconi
Serge Gangloff
Benoît Arcangioli
spellingShingle Rostyslav Makarenko
Claire Denis
Stefania Francesconi
Serge Gangloff
Benoît Arcangioli
Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways
Nature Communications
author_facet Rostyslav Makarenko
Claire Denis
Stefania Francesconi
Serge Gangloff
Benoît Arcangioli
author_sort Rostyslav Makarenko
title Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways
title_short Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways
title_full Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways
title_fullStr Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways
title_full_unstemmed Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways
title_sort nitrogen starvation reveals the mitotic potential of mutants in the s/mapk pathways
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-04-01
description Nitrogen-starved fission yeast cells survive for weeks without dividing. Here, the authors show that some of these surviving cells accumulate mutations in the stress- and mitogen-activated protein kinase pathways and outcompete their parental cells, which provide nutrients for the mutant cells.
url https://doi.org/10.1038/s41467-020-15880-y
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AT clairedenis nitrogenstarvationrevealsthemitoticpotentialofmutantsinthesmapkpathways
AT stefaniafrancesconi nitrogenstarvationrevealsthemitoticpotentialofmutantsinthesmapkpathways
AT sergegangloff nitrogenstarvationrevealsthemitoticpotentialofmutantsinthesmapkpathways
AT benoitarcangioli nitrogenstarvationrevealsthemitoticpotentialofmutantsinthesmapkpathways
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