Synthesis and characterization of porous structures of rutile TiO2 /Na0.8Ti4O8/Na2Ti6O13 for biomedical applications

• Main Authors: Diego Fernando Triviño-Bolaños, Rubén Jesús Camargo-Amado
• Format: Article
• Language: English
• Published: Elsevier 2019-01-01
• Series: MethodsX
• Online Access: http://www.sciencedirect.com/science/article/pii/S2215016119300895

This method involves the use of molding, pressing and sintering techniques applied to different powder mixtures of TiO2 with sodium bicarbonate NaHCO3 (15 wt% and 30 wt% NaHCO3), to obtain porous structures of rutile TiO2/Na0.8Ti4O8/Na2Ti6O13 and Na0.8Ti4O8/Na2Ti6O13 for possible biomedical implant applications. The method validation includes X-ray diffraction patterns (XRD) analysis refined by the Rietveld method using X'Pert HighScore Plus. The surface morphology was observed by using a scanning electron microscopy (SEM) equipped with an energy dispersive spectrometer (EDS), and, finally, a Chinese hamster ovary (CHO) cell line was cultured with the porous structures to determine the effect of material composition on the cellular response using a LDH cytotoxicity assay. • The method does not require the use of toxic solvents to remove residues. • The porous structure formed is composed mainly of crystalline phases Na2Ti6O13/TiO2 reported as biocompatible. • It did not need complicated solid-liquid separation processes. Method name: Synthesis and characterization of porous structures of rutile TiO2/Na0.8Ti4O8/Na2Ti6O13 for biomedical applications, Keywords: Sodium-titanate, Porosity, Crystalline phase