An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.

Bibliographic Details
Main Authors:	Yifeng Wang, Sumedha Gunewardena, Feng Li, David J. Matye, Cheng Chen, Xiaojuan Chao, Taeyoon Jung, Yuxia Zhang, Maciej Czerwiński, Hong-Min Ni, Wen-Xing Ding, Tiangang Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17363-6

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spelling	doaj-e9a63e08c6d4478bbf30ac94313ec4ce2021-07-18T11:44:52ZengNature Publishing GroupNature Communications2041-17232020-07-0111111610.1038/s41467-020-17363-6An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasisYifeng Wang0Sumedha Gunewardena1Feng Li2David J. Matye3Cheng Chen4Xiaojuan Chao5Taeyoon Jung6Yuxia Zhang7Maciej Czerwiński8Hong-Min Ni9Wen-Xing Ding10Tiangang Li11Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Molecular and Integrative Physiology, University of Kansas Medical CenterDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterSekisui XenoTech LLCDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterTFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.https://doi.org/10.1038/s41467-020-17363-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li
spellingShingle	Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis Nature Communications
author_facet	Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li
author_sort	Yifeng Wang
title	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_short	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_full	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_fullStr	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_full_unstemmed	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_sort	fgf15/19-tfeb regulatory loop controls hepatic cholesterol and bile acid homeostasis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.
url	https://doi.org/10.1038/s41467-020-17363-6
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An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

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