An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.
Bibliographic Details
| Main Authors: |
Yifeng Wang,
Sumedha Gunewardena,
Feng Li,
David J. Matye,
Cheng Chen,
Xiaojuan Chao,
Taeyoon Jung,
Yuxia Zhang,
Maciej Czerwiński,
Hong-Min Ni,
Wen-Xing Ding,
Tiangang Li |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-17363-6
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