Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help.

Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help.

We have previously demonstrated that temporary depletion of CD4 T cells in mice with progressive B16 melanoma, followed by surgical tumor excision, induces protective memory CD8 T cell responses to melanoma/melanocyte antigens. We also showed that persistence of these CD8 T cells is supported, in an...

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Bibliographic Details
Main Authors: Anik L Côté, Katelyn T Byrne, Shannon M Steinberg, Peisheng Zhang, Mary Jo Turk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3202545?pdf=render

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