Injection Molded Capsules for Colon Delivery Combining Time-Controlled and Enzyme-Triggered Approaches

Injection Molded Capsules for Colon Delivery Combining Time-Controlled and Enzyme-Triggered Approaches

A new type of colon targeting system is presented, combining time-controlled and enzyme-triggered approaches. Empty capsule shells were prepared by injection molding of blends of a high-amylose starch and hydroxypropyl methylcellulose (HPMC) of different chain lengths. The dissolution/erosion of the...

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Bibliographic Details
Main Authors: Federica Casati, Alice Melocchi, Saliha Moutaharrik, Marco Uboldi, Anastasia Foppoli, Alessandra Maroni, Lucia Zema, Christel Neut, Florence Siepmann, Juergen Siepmann, Andrea Gazzaniga
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
capsules
colon delivery
injection molding
swellable/soluble hydrophilic polymer
bacteria-sensitive polymer
Online Access:https://www.mdpi.com/1422-0067/21/6/1917

Internet

https://www.mdpi.com/1422-0067/21/6/1917

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