Direct and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria.

Direct and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria.

Repetitive DNA sequences with the potential to form alternative DNA conformations, such as slipped structures and cruciforms, can induce genetic instability by promoting replication errors and by serving as a substrate for DNA repair proteins, which may lead to DNA double-strand breaks (DSBs). Howev...

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Bibliographic Details
Main Authors: Ewelina A Wojcik, Anna Brzostek, Albino Bacolla, Pawel Mackiewicz, Karen M Vasquez, Malgorzata Korycka-Machala, Adam Jaworski, Jaroslaw Dziadek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3519483?pdf=render

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