NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins

NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins

Abstract Background The major human fungal pathogen Candida albicans possesses a diploid genome, but responds to growth in challenging environments by employing chromosome aneuploidy as an adaptation mechanism. For example, we have shown that C. albicans adapts to growth on the toxic sugar l-sorbose...

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Bibliographic Details
Main Authors: Hironao Wakabayashi, Christopher Tucker, Gabor Bethlendy, Anatoliy Kravets, Stephen L. Welle, Michael Bulger, Jeffrey J. Hayes, Elena Rustchenko
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Epigenetics & Chromatin
Subjects:
Candida albicans
NuA4
H4 and H3 acetylation
Chromosome 5 monosomy
Online Access:http://link.springer.com/article/10.1186/s13072-017-0156-y

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http://link.springer.com/article/10.1186/s13072-017-0156-y

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