XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity

XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity

Abstract Background XMU-MP-1 is an inhibitor of the Hippo pathway kinases MST1/2 and has been shown to promote the downstream activation of the pro-proliferative, pro-regenerative and anti-apoptotic transcriptional regulator YAP1. We tested whether XMU-MP-1 can activate YAP1 in a model human mini-or...

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Bibliographic Details
Main Authors: Ellen Mitchell, Charlotte E. L. Mellor, Talveen S. Purba
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell Division
Subjects:
XMU-MP-1
Hippo
YAP1
Cell cycle
Proliferation
Hair follicle
Online Access:http://link.springer.com/article/10.1186/s13008-020-00067-0

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