The Functions of Non-coding RNAs in rRNA Regulation

• Main Authors: Qi Yan, Chengming Zhu, Shouhong Guang, Xuezhu Feng
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-04-01
• Series: Frontiers in Genetics
• Subjects: rRNA; non-coding RNA; PAPAS; SLERT; 5S-OT; risiRNA
• Online Access: https://www.frontiersin.org/article/10.3389/fgene.2019.00290/full

Ribosomes are ribonucleoprotein machines that decode the genetic information embedded in mRNAs into polypeptides. Ribosome biogenesis is tightly coordinated and controlled from the transcription of pre-rRNAs to the assembly of ribosomes. Defects or disorders in rRNA production result in a number of human ribosomopathy diseases. During the processes of rRNA synthesis, non-coding RNAs, especially snoRNAs, play important roles in pre-rRNA transcription, processing, and maturation. Recent research has started to reveal that other long and short non-coding RNAs, including risiRNA, LoNA, and SLERT (among others), are also involved in pre-rRNA transcription and rRNA production. Here, we summarize the current understanding of the mechanisms of non-coding RNA-mediated rRNA generation and regulation and their biological roles.