Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy

Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy

Epidermal growth factor receptor antibodies (EGFR-Abs) confer a survival benefit in patients with <i>RAS</i> wild-type metastatic colorectal cancer (mCRC), but resistance invariably occurs. Previous data showed that only a minority of cancer cells harboured known genetic resistance drive...

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Bibliographic Details
Main Authors: Franciele H. Knebel, Louise J. Barber, Alice Newey, Dimitrios Kleftogiannis, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Fabiana Bettoni, Maurício Fernando Silva Almeida Ribeiro, Leonardo da Fonseca, Frederico Costa, Fernanda Cunha Capareli, Paulo M. Hoff, Jorge Sabbaga, Anamaria A. Camargo, Marco Gerlinger
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
colorectal cancer
ctDNA-Sequencing
ctDNA-ddPCR
acquired resistance
genetic resistance-gap
EGFR-antibodies
Online Access:https://www.mdpi.com/2072-6694/12/12/3736

Internet

https://www.mdpi.com/2072-6694/12/12/3736

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