Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease

Huntington disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the huntingtin gene. The onset of symptoms is preceded by synaptic dysfunction. Homeostatic synaptic plasticity (HSP) refers to processes that maintain the stability of networks of neurons, thought to be requi...

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Bibliographic Details
Main Authors: Amy I. Smith-Dijak, Wissam B. Nassrallah, Lily Y. J. Zhang, Michal Geva, Michael R. Hayden, Lynn A. Raymond
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Huntington disease
homeostatic
synaptic
plasticity
calcium
BDNF
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00209/full

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