Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the...

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Main Authors: G. Frega, O. Kepp, D. Turchetti, A. Rizzo, M.A. Pantaleo, G. Brandi
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Translational Oncology
Subjects:
Immunogenic cell death
Immunomodulatory chemotherapies
Cancer genome
Gestational choriocarcinoma
Bystander effect
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321002163
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spelling doaj-e96400ae4f954e268102835e727ed9642021-09-29T04:24:35ZengElsevierTranslational Oncology1936-52332021-12-011412101224Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasmsG. Frega0O. Kepp1D. Turchetti2A. Rizzo3M.A. Pantaleo4G. Brandi5Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Italy; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni n.15, 40138 Bologna, Italy; Corresponding author at: Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Italy.Equipe labellisée par la Ligue contre le cancer, INSERM UMR1138, Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, FranceDepartment of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Italy; U.O. Genetica Medica, Policlinico S. Orsola-Malpighi, Centro di Ricerca sui Tumori Ereditari, Bologna ItalyDepartment of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Italy; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni n.15, 40138 Bologna, ItalyDepartment of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Italy; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni n.15, 40138 Bologna, ItalyDepartment of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Italy; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni n.15, 40138 Bologna, ItalyThe genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.http://www.sciencedirect.com/science/article/pii/S1936523321002163Immunogenic cell deathImmunomodulatory chemotherapiesCancer genomeGestational choriocarcinomaBystander effect
collection DOAJ
language English
format Article
sources DOAJ
author G. Frega
O. Kepp
D. Turchetti
A. Rizzo
M.A. Pantaleo
G. Brandi
spellingShingle G. Frega
O. Kepp
D. Turchetti
A. Rizzo
M.A. Pantaleo
G. Brandi
Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
Translational Oncology
Immunogenic cell death
Immunomodulatory chemotherapies
Cancer genome
Gestational choriocarcinoma
Bystander effect
author_facet G. Frega
O. Kepp
D. Turchetti
A. Rizzo
M.A. Pantaleo
G. Brandi
author_sort G. Frega
title Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_short Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_full Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_fullStr Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_full_unstemmed Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_sort hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
publisher Elsevier
series Translational Oncology
issn 1936-5233
publishDate 2021-12-01
description The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.
topic Immunogenic cell death
Immunomodulatory chemotherapies
Cancer genome
Gestational choriocarcinoma
Bystander effect
url http://www.sciencedirect.com/science/article/pii/S1936523321002163
work_keys_str_mv AT gfrega hypothesisonthepossiblerelevanceoftheimmunogeniccelldeathinthetreatmentofgestationaltrophoblasticneoplasms
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AT dturchetti hypothesisonthepossiblerelevanceoftheimmunogeniccelldeathinthetreatmentofgestationaltrophoblasticneoplasms
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