Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the...

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Bibliographic Details
Main Authors: G. Frega, O. Kepp, D. Turchetti, A. Rizzo, M.A. Pantaleo, G. Brandi
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Translational Oncology
Subjects:
Immunogenic cell death
Immunomodulatory chemotherapies
Cancer genome
Gestational choriocarcinoma
Bystander effect
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321002163
Description
Summary:The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.
ISSN:1936-5233

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