Expression of Y2R mRNA Expression in Subcutaneous and Visceral Adipose Tissues Compared between Normal Weight and Obese Female Subjects

• Main Authors: Saimai Chatree, Malika Churintaraphan
• Format: Article
• Language: English
• Published: Mahidol University 2017-04-01
• Series: Siriraj Medical Journal
• Subjects: Y2R; PYY; NPY; obesity
• Online Access: https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/82353

Y2R mRNA expression in subcutaneous and visceral fat tissues as well as serum PYY levels between obese and normal weight subjects. We demonstrated that Y2R mRNA in visceral fat was greater (p<0.05) in normal weight subjects than in obese subjects with comparable expression in subcutaneous adipose tissue. Y2R mRNA was (p<0.05) expressed higher in subcutaneous than visceral fat tissue in obese subjects. Moreover, Y2R mRNA expression in subcutaneous fat tissue was positively correlated to its expression in visceral adipose tissues (R=0.932, p<0.001). In visceral fat, Y2R expression was negatively correlated with serum NPY levels (R=-0.415, p<0.05). Serum PYY was similar between obese and normal weight groups. In conclusion, higher Y2R mRNA expression in visceral fat tissue might be involved in lower adiposity. Further investigation regarding activation of Y2R action in visceral adipose tissue may reveal novel strategies for adiposity reduction.