Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer

Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pat...

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Main Authors:	Song Wu, Tong Ou, Nianzeng Xing, Jiang Lu, Shengqing Wan, Changxi Wang, Xi Zhang, Feiya Yang, Yi Huang, Zhiming Cai
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08576-5

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spelling	doaj-e9480435b64d444b8ae4cdedd63584ba2021-05-11T12:26:53ZengNature Publishing GroupNature Communications2041-17232019-02-0110111210.1038/s41467-019-08576-5Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancerSong Wu0Tong Ou1Nianzeng Xing2Jiang Lu3Shengqing Wan4Changxi Wang5Xi Zhang6Feiya Yang7Yi Huang8Zhiming Cai9Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen UniversityUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen UniversityDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical UniversityUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen UniversityShenzhen Following Precision Medical Research Institute, Luohu Hospital GroupUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen UniversityUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen UniversityDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical UniversityUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen UniversityUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen UniversityBladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.https://doi.org/10.1038/s41467-019-08576-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Song Wu Tong Ou Nianzeng Xing Jiang Lu Shengqing Wan Changxi Wang Xi Zhang Feiya Yang Yi Huang Zhiming Cai
spellingShingle	Song Wu Tong Ou Nianzeng Xing Jiang Lu Shengqing Wan Changxi Wang Xi Zhang Feiya Yang Yi Huang Zhiming Cai Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer Nature Communications
author_facet	Song Wu Tong Ou Nianzeng Xing Jiang Lu Shengqing Wan Changxi Wang Xi Zhang Feiya Yang Yi Huang Zhiming Cai
author_sort	Song Wu
title	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_short	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_full	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_fullStr	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_full_unstemmed	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_sort	whole-genome sequencing identifies adgrg6 enhancer mutations and frs2 duplications as angiogenesis-related drivers in bladder cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.
url	https://doi.org/10.1038/s41467-019-08576-5
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Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer

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