Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca2+ Signaling Pathway

Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca2+ Signaling Pathway

XueShuanTong (XST) comprising therapeutically active ginsenosides, a lyophilized extract of Panax notoginseng roots, is extensively used in traditional Chinese medicine to treat ischemic heart and cerebrovascular diseases. Our recent study shows that treatment with XST inhibits shear-induced thrombo...

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Bibliographic Details
Main Authors: Lei Liu, Qiongling Zhang, Shunli Xiao, Zhengxiao Sun, Shilan Ding, Ying Chen, Lan Wang, Xiaojie Yin, Fulong Liao, Lin-Hua Jiang, Mei Xue, Yun You
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
xueshuantong
shear
platelet aggregation
piezo1 channel
Ca2+
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.606245/full

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