Activation of the γ-secretase complex and presence of γ-secretase-activating protein may contribute to Aβ42 production in sporadic inclusion-body myositis muscle fibers

Activation of the γ-secretase complex and presence of γ-secretase-activating protein may contribute to Aβ42 production in sporadic inclusion-body myositis muscle fibers

The muscle-fiber phenotype of sporadic inclusion-body myositis (s-IBM), the most common muscle disease associated with aging, shares several pathological abnormalities with Alzheimer disease (AD) brain, including accumulation of amyloid-β 42 (Aβ42) and its cytotoxic oligomers. The exact mechanisms l...

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Bibliographic Details
Main Authors: Anna Nogalska, Carla D'Agostino, W. King Engel, Valerie Askanas
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Neurobiology of Disease
Subjects:
Sporadic inclusion-body myositis
Presenilin
Nicastrin
Pen2
γ-secretase activating protein (GSAP)
Amyloid β-42
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002239

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