Characterization of the C1q-Binding Ability and the IgG1-4 Subclass Profile of Preformed Anti-HLA Antibodies by Solid-Phase Assays

Characterization of the C1q-Binding Ability and the IgG1-4 Subclass Profile of Preformed Anti-HLA Antibodies by Solid-Phase Assays

Humoral alloimmunity, particularly that triggered by preformed antibodies against human leukocyte antigens (HLA), is associated with an increased prevalence of rejection and reduced transplant survival. The high sensitivity of solid phase assays, based on microbeads coated with single antigens (SAB)...

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Bibliographic Details
Main Authors: Ana Navas, Juan Molina, María-Luisa Agüera, Ipek Guler, Aurora Jurado, Alberto Rodríguez-Benot, Corona Alonso, Rafael Solana
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
anti-HLA antibodies
C1q-binding ability
humoral alloimmunity
IgG1-4 subclass profile
kidney transplantation
single antigen bead assay
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01712/full

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