Supported Phospholipid Bilayer Interaction with Components Found in Typical Room-Temperature Ionic Liquids – a QCM-D and AFM Study

• Main Author: Kervin O. Evans
• Format: Article
• Language: English
• Published: MDPI AG 2008-04-01
• Series: International Journal of Molecular Sciences
• Subjects: Quartz crystal microbalance with dissipation (QCM-D); Supported phospholipid bilayer (SPB); Room-temperature ionic liquid (RT-IL); Atomic force microscopy (AFM); 1; 2-dielaidoylphosphatidylcholine (DEPC).
• Online Access: http://www.mdpi.com/1422-0067/9/4/498/

Quartz crystal microbalance with dissipation (QCM-D) monitoring and atomic force microscopy (AFM) were combined to evaluate the defects created by an ionic liquid anion and a cation in a supported phospholipid bilayer composed of zwitterionic lipids on a silica surface. The cation 1-octyl-3-methyl imidazolium (OMIM+) was shown to remove lipids from the bilayer, increase the roughness to approximately 2.8 nm (~0.2 for stable supported bilayer) and possibly redeposit lipids with entrapped water. The anion bis(trifluoromethylsulfonyl)imide (Tf2N-) was found to leave distinct defects within the bilayer that had large pore-like interiors which left the surrounding bilayer intact. However, the ionic liquid 1-butyl-1-methyl pyrrolidinium bis(trifluoromethylsulfonyl)imide (BMP-Tf2N) formed a film over the supported bilayer. This work demonstrates, for the first time, the direct effects common components of ionic liquids have on a supported phospholipids bilayer.