Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe

Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe

In Europe, the first case of coronavirus disease (COVID-19) and the first COVID-19-related death were reported in France on January 24th and February 15th, 2020, respectively. Officially, the first case of COVID-19 infection in the Republic of Serbia was registered on March 6th. Herein, we presented...

Full description

Bibliographic Details
Main Authors: Milenko Bogdanović, Ivan Skadrić, Tatjana Atanasijević, Oliver Stojković, Vesna Popović, Slobodan Savić, Zoran Mihailović, Bojana Radnić, Tijana Aćimović, Irina Damjanjuk, Sanja Despotović, Aleksandra Barać
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Medicine
Subjects:
COVID-19
SARS-CoV-2
vitreous humor
autopsy
Europe (central)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.612758/full
id doaj-e9264f73f5fd4501bd3fd1eed3881824
record_format Article
spelling doaj-e9264f73f5fd4501bd3fd1eed38818242021-02-19T06:13:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-02-01810.3389/fmed.2021.612758612758Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in EuropeMilenko Bogdanović0Ivan Skadrić1Tatjana Atanasijević2Oliver Stojković3Oliver Stojković4Vesna Popović5Slobodan Savić6Zoran Mihailović7Bojana Radnić8Tijana Aćimović9Irina Damjanjuk10Sanja Despotović11Aleksandra Barać12Aleksandra Barać13Faculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Human Genetics, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Forensic Medicine “Milovan Milovanović”, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, Institute of Histology and Embryology, University of Belgrade, Belgrade, SerbiaClinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaIn Europe, the first case of coronavirus disease (COVID-19) and the first COVID-19-related death were reported in France on January 24th and February 15th, 2020, respectively. Officially, the first case of COVID-19 infection in the Republic of Serbia was registered on March 6th. Herein, we presented the first case of retrospective detection of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the post-mortem-obtained vitreous humor (VH), which took place on February 5th, 2020. This is the first death in Europe proven to be caused by COVID-19 by means of post-mortem histopathological and molecular analyses. Based on this finding, it appears that SARS-CoV-2 has been spreading faster and started spreading much earlier than it had been considered and that COVID-19 was probably the cause of the much-reported pneumonia of unknown origin in January and February 2020.https://www.frontiersin.org/articles/10.3389/fmed.2021.612758/fullCOVID-19SARS-CoV-2vitreous humorautopsyEurope (central)
collection DOAJ
language English
format Article
sources DOAJ
author Milenko Bogdanović
Ivan Skadrić
Tatjana Atanasijević
Oliver Stojković
Oliver Stojković
Vesna Popović
Slobodan Savić
Zoran Mihailović
Bojana Radnić
Tijana Aćimović
Irina Damjanjuk
Sanja Despotović
Aleksandra Barać
Aleksandra Barać
spellingShingle Milenko Bogdanović
Ivan Skadrić
Tatjana Atanasijević
Oliver Stojković
Oliver Stojković
Vesna Popović
Slobodan Savić
Zoran Mihailović
Bojana Radnić
Tijana Aćimović
Irina Damjanjuk
Sanja Despotović
Aleksandra Barać
Aleksandra Barać
Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe
Frontiers in Medicine
COVID-19
SARS-CoV-2
vitreous humor
autopsy
Europe (central)
author_facet Milenko Bogdanović
Ivan Skadrić
Tatjana Atanasijević
Oliver Stojković
Oliver Stojković
Vesna Popović
Slobodan Savić
Zoran Mihailović
Bojana Radnić
Tijana Aćimović
Irina Damjanjuk
Sanja Despotović
Aleksandra Barać
Aleksandra Barać
author_sort Milenko Bogdanović
title Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe
title_short Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe
title_full Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe
title_fullStr Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe
title_full_unstemmed Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe
title_sort case report: post-mortem histopathological and molecular analyses of the very first documented covid-19-related death in europe
publisher Frontiers Media S.A.
series Frontiers in Medicine
issn 2296-858X
publishDate 2021-02-01
description In Europe, the first case of coronavirus disease (COVID-19) and the first COVID-19-related death were reported in France on January 24th and February 15th, 2020, respectively. Officially, the first case of COVID-19 infection in the Republic of Serbia was registered on March 6th. Herein, we presented the first case of retrospective detection of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the post-mortem-obtained vitreous humor (VH), which took place on February 5th, 2020. This is the first death in Europe proven to be caused by COVID-19 by means of post-mortem histopathological and molecular analyses. Based on this finding, it appears that SARS-CoV-2 has been spreading faster and started spreading much earlier than it had been considered and that COVID-19 was probably the cause of the much-reported pneumonia of unknown origin in January and February 2020.
topic COVID-19
SARS-CoV-2
vitreous humor
autopsy
Europe (central)
url https://www.frontiersin.org/articles/10.3389/fmed.2021.612758/full
work_keys_str_mv AT milenkobogdanovic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT ivanskadric casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT tatjanaatanasijevic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT oliverstojkovic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT oliverstojkovic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT vesnapopovic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT slobodansavic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT zoranmihailovic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT bojanaradnic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT tijanaacimovic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT irinadamjanjuk casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT sanjadespotovic casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT aleksandrabarac casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
AT aleksandrabarac casereportpostmortemhistopathologicalandmolecularanalysesoftheveryfirstdocumentedcovid19relateddeathineurope
_version_ 1724261682978488320

Similar Items