Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking

Regeneration of skeletal muscle is accompanied by a transitory inflammatory phase. Here the authors show that the complement C3 component is activated following muscle injury, and signals through the alternative complement pathway to regulate immune cell infiltration and muscle regeneration.

Bibliographic Details
Main Authors:	Congcong Zhang, Chunxiao Wang, Yulin Li, Takashi Miwa, Chang Liu, Wei Cui, Wen-Chao Song, Jie Du
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01526-z

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spelling	doaj-e91c93ba282f4a14988e85085d4441622021-05-11T07:14:27ZengNature Publishing GroupNature Communications2041-17232017-12-018111210.1038/s41467-017-01526-zComplement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and traffickingCongcong Zhang0Chunxiao Wang1Yulin Li2Takashi Miwa3Chang Liu4Wei Cui5Wen-Chao Song6Jie Du7Beijing AnZhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel DiseasesBeijing AnZhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel DiseasesBeijing AnZhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel DiseasesDepartment of Pharmacology and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of MedicineBeijing AnZhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel DiseasesBeijing AnZhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel DiseasesDepartment of Pharmacology and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of MedicineBeijing AnZhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel DiseasesRegeneration of skeletal muscle is accompanied by a transitory inflammatory phase. Here the authors show that the complement C3 component is activated following muscle injury, and signals through the alternative complement pathway to regulate immune cell infiltration and muscle regeneration.https://doi.org/10.1038/s41467-017-01526-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Congcong Zhang Chunxiao Wang Yulin Li Takashi Miwa Chang Liu Wei Cui Wen-Chao Song Jie Du
spellingShingle	Congcong Zhang Chunxiao Wang Yulin Li Takashi Miwa Chang Liu Wei Cui Wen-Chao Song Jie Du Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking Nature Communications
author_facet	Congcong Zhang Chunxiao Wang Yulin Li Takashi Miwa Chang Liu Wei Cui Wen-Chao Song Jie Du
author_sort	Congcong Zhang
title	Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking
title_short	Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking
title_full	Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking
title_fullStr	Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking
title_full_unstemmed	Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking
title_sort	complement c3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Regeneration of skeletal muscle is accompanied by a transitory inflammatory phase. Here the authors show that the complement C3 component is activated following muscle injury, and signals through the alternative complement pathway to regulate immune cell infiltration and muscle regeneration.
url	https://doi.org/10.1038/s41467-017-01526-z
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_version_	1721452634321190912

Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking

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