Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking

Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking

Regeneration of skeletal muscle is accompanied by a transitory inflammatory phase. Here the authors show that the complement C3 component is activated following muscle injury, and signals through the alternative complement pathway to regulate immune cell infiltration and muscle regeneration.

Bibliographic Details
Main Authors: Congcong Zhang, Chunxiao Wang, Yulin Li, Takashi Miwa, Chang Liu, Wei Cui, Wen-Chao Song, Jie Du
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01526-z
Description
Summary:Regeneration of skeletal muscle is accompanied by a transitory inflammatory phase. Here the authors show that the complement C3 component is activated following muscle injury, and signals through the alternative complement pathway to regulate immune cell infiltration and muscle regeneration.
ISSN:2041-1723

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