Human Keratoconus Cell Contractility is Mediated by Transforming Growth Factor-Beta Isoforms

Human Keratoconus Cell Contractility is Mediated by Transforming Growth Factor-Beta Isoforms

Keratoconus (KC) is a progressive disease linked to defects in the structural components of the corneal stroma. The extracellular matrix (ECM) is secreted and assembled by corneal keratocytes and regulated by transforming growth factor-β (TGF-β). We have previously identified alterations in the TGF-...

Full description

Bibliographic Details
Main Authors:	Desiree' Lyon, Tina B. McKay, Akhee Sarkar-Nag, Shrestha Priyadarsini, Dimitrios Karamichos
Format:	Article
Language:	English
Published:	MDPI AG 2015-06-01
Series:	Journal of Functional Biomaterials
Subjects:	keratoconus transforming growth factor-β collagen gels extracellular matrix matrix metalloproteases
Online Access:	http://www.mdpi.com/2079-4983/6/2/422

Similar Items

Arginine Supplementation Promotes Extracellular Matrix and Metabolic Changes in Keratoconus
by: Tina B. McKay, et al.
Published: (2021-08-01)

Mechanisms of Collagen Crosslinking in Diabetes and Keratoconus
by: Tina B. McKay, et al.
Published: (2019-10-01)

Tissue-Derived Biological Particles Restore Cornea Properties in an Enzyme-Mediated Corneal Ectatic Model
by: Hongbo Yin, et al.
Published: (2019-09-01)

Cellular localisation of type XIII collagen, and its induced expression in human neoplasias and corneal diseases
by: Väisänen, T. (Timo)
Published: (2005)

Novel in Vitro Model for Keratoconus Disease
by: James D. Zieske, et al.
Published: (2012-11-01)

Matrix degrading proteases and collagen-derived angiogenesis inhibitors in the regulation of carcinoma cell growth
by: Nyberg, P. (Pia)
Published: (2005)

A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression
by: Sumeda Nandadasa, et al.
Published: (2021-06-01)

Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly
by: Alexes C. Daquinag, et al.
Published: (2020-12-01)

Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment
by: Marina Marozzi, et al.
Published: (2021-07-01)

Changes in tear biomarker levels in keratoconus after corneal collagen crosslinking
by: Jose Ignacio Recalde, et al.
Published: (2019-01-01)

Long-term Outcomes of Collagen Crosslinking for Early Keratoconus
by: Akbar Derakhshan, et al.
Published: (2021-05-01)

Keratoconus Screening in Elementary School Children
by: Majid Moshirfar, et al.
Published: (2019-07-01)

The Antimuscarinic Agent Tolterodine Regulates Bladder Extracellular Matrix in Partial Bladder Outlet Obstruction in Rats
by: Tong-Xin Yang, et al.
Published: (2018-03-01)

Cellular Pushing Forces during Mitosis Drive Mitotic Elongation in Collagen Gels
by: Sungmin Nam, et al.
Published: (2021-02-01)

Matrix Metalloproteinases & Implication in Periodontitis- A Short Review
by: Hitesh Desarda, et al.
Published: (2013-01-01)

Keratoconus: Tissue Engineering and Biomaterials
by: Dimitrios Karamichos, et al.
Published: (2014-09-01)

Interleukin 6 Plays a Role in the Migration of Magnetically Levitated Mesenchymal Stem Cells Spheroids
by: Jake Casson, et al.
Published: (2018-03-01)

Facet joint degeneration in adolescent idiopathic scoliosis
by: Daniel G. Bisson, et al.
Published: (2018-06-01)

Standard versus transepithelial collagen cross-linking in the management of keratoconus
by: Abd El-Magid M Tag El-Din, et al.
Published: (2018-01-01)

Substrate specificity of lysyl hydroxylase isoforms and multifunctionality of lysyl hydroxylase 3
by: Risteli, M. (Maija)
Published: (2008)

The Anticancer Role of Capsaicin in Experimentallyinduced Lung Carcinogenesis
by: Pandi Anandakumar, et al.
Published: (2015-06-01)

Serological CTX-II does not measure the same as urinary CTX-II
by: Yunyun Luo, et al.
Published: (2020-09-01)

MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus
by: Mehrdad Mohammadpour, et al.
Published: (2020-10-01)

Corneal collagen crosslinking for keratoconus. A review
by: M. M. Bikbov, et al.
Published: (2014-10-01)

Corneal collagen crosslinking for keratoconus. A review
by: M. M. Bikbov, et al.
Published: (2014-10-01)

Classic homocystinuria and keratoconus: a case report
by: Patrícia Ioschpe Gus, et al.

Cell cytoskeletal changes effected by static compressive stress lead to changes in the contractile properties of tissue regenerative collagen membranes
by: K Gellynck, et al.
Published: (2013-06-01)

Experience of modified procedure treatment of progressive keratoconus based on corneal collagen cross-linking with femtosecond formation of intrastromal pocket
by: Solodkova E.G., et al.
Published: (2017-06-01)

Long-term follow-up results of corneal collagen cross-linking in keratoconus
by: Ayşe Ebru Kılavuzoğlu, et al.
Published: (2015-12-01)

Double contact lens-assisted corneal cross-linking in ultrathin corneas with keratoconus
by: Abdulrahman M Alamri
Published: (2018-01-01)

Research progress of corneal collagen cross-linking in the treatment of keratoconus
by: Jin-Jing Li, et al.
Published: (2020-03-01)

Collagen fiber changes related to keratoconus with secondary corneal amyloidosis
by: Araki-Sasaki K, et al.
Published: (2018-08-01)

Mathematical modelling of cancer invasion: The role of membrane-bound matrix metalloproteinases
by: Mark AJ Chaplain, et al.
Published: (2013-04-01)

Matriz extracelular na aorta ascendente humana: quantificação morfométrica do colágeno em aortas normais e análise topográfica da matrilisina, estromelisina e plasmina em dissecções e aneurismas não-inflamatórios
by: Borges, Luciano de Figueiredo
Published: (2006)

Matriz extracelular na aorta ascendente humana: quantificação morfométrica do colágeno em aortas normais e análise topográfica da matrilisina, estromelisina e plasmina em dissecções e aneurismas não-inflamatórios
by: Luciano de Figueiredo Borges
Published: (2006)

Collagen 24 α1 Is Increased in Insulin-Resistant Skeletal Muscle and Adipose Tissue
by: Xiong Weng, et al.
Published: (2020-08-01)

Evaluation of Corneal Biomechanical Changes After Collagen Crosslinking in Patients with Progressive Keratoconus by Ocular Response Analyzer
by: Raciha Beril Küçümen, et al.
Published: (2018-08-01)

Bilateral viral keratitis following corneal collagen crosslinking for progressive keratoconus
by: Sanjeeta Sitaula, et al.
Published: (2019-08-01)

Pentacam topographic changes after collagen cross-linking in patients with keratoconus
by: Hassan Razmjoo, et al.
Published: (2015-01-01)

Simultaneous versus sequential photorefractive keratectomy and cross-linking for the management of early keratoconus
by: Ashraf Bor′i
Published: (2016-01-01)