Human Keratoconus Cell Contractility is Mediated by Transforming Growth Factor-Beta Isoforms

Human Keratoconus Cell Contractility is Mediated by Transforming Growth Factor-Beta Isoforms

Keratoconus (KC) is a progressive disease linked to defects in the structural components of the corneal stroma. The extracellular matrix (ECM) is secreted and assembled by corneal keratocytes and regulated by transforming growth factor-β (TGF-β). We have previously identified alterations in the TGF-...

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Bibliographic Details
Main Authors: Desiree' Lyon, Tina B. McKay, Akhee Sarkar-Nag, Shrestha Priyadarsini, Dimitrios Karamichos
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Journal of Functional Biomaterials
Subjects:
keratoconus
transforming growth factor-β
collagen gels
extracellular matrix
matrix metalloproteases
Online Access:http://www.mdpi.com/2079-4983/6/2/422

Internet

http://www.mdpi.com/2079-4983/6/2/422

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