The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases
The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth rinse, gingival crevicular fluid (GCF), and peri-implantitis fluid (PISF)) is demanding. Several hosts and microbial factors may influence their expression, release, and levels. The type of saliv...
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Hindawi Limited
2018-01-01
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| Series: | Disease Markers |
| Online Access: | http://dx.doi.org/10.1155/2018/1306396 |
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doaj-e90faaab8c04474c8106bbda7a50e8742020-11-25T02:49:56ZengHindawi LimitedDisease Markers0278-02401875-86302018-01-01201810.1155/2018/13063961306396The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant DiseasesSaeed Alassiri0Pirjo Parnanen1Nilminie Rathnayake2Gunnar Johannsen3Anna-Maria Heikkinen4Richard Lazzara5Peter van der Schoor6Jan Gerrit van der Schoor7Taina Tervahartiala8Dirk Gieselmann9Timo Sorsa10Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, University of Helsinki, Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Helsinki University Hospital, University of Helsinki, Helsinki, FinlandDepartment of Dental Medicine, Division of Periodontology, Karolinska Institutet, Stockholm, SwedenDepartment of Dental Medicine, Division of Periodontology, Karolinska Institutet, Stockholm, SwedenDepartment of Oral and Maxillofacial Diseases, Helsinki University Hospital, University of Helsinki, Helsinki, FinlandInstitute of Molecular Dentistry, Solingen, GermanyDepartment of Dental Medicine, Division of Periodontology, Karolinska Institutet, Stockholm, SwedenInstitute of Molecular Dentistry, Solingen, GermanyDepartment of Oral and Maxillofacial Diseases, Helsinki University Hospital, University of Helsinki, Helsinki, FinlandInstitute of Molecular Dentistry, Solingen, GermanyDepartment of Oral and Maxillofacial Diseases, Helsinki University Hospital, University of Helsinki, Helsinki, FinlandThe analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth rinse, gingival crevicular fluid (GCF), and peri-implantitis fluid (PISF)) is demanding. Several hosts and microbial factors may influence their expression, release, and levels. The type of saliva/oral fluids utilized for the diagnostics affects the analysis. High sensitivity and specificities together with sophisticated methods and techniques are essential for valuable outcome. We describe here recently developed practical, convenient, inexpensive, noninvasive, and quantitative mouth rinse and PISF/GCF/chair-side/point-of-care (PoC) lateral-flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyser) to detect, predict, and monitor successfully the course, treatment, and prevention of periodontitis and peri-implantitis, respectively. The tests have been independently and successfully validated to differentiate periodontal and peri-implant health and disease in Finland, Germany, Netherland, Sweden, Turkey, Nigeria, Malawi, and USA. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires additional studies utilizing these noninvasive screening, diagnostic, and preventive aMMP-8 PoC/chair-side technologies.http://dx.doi.org/10.1155/2018/1306396 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Saeed Alassiri Pirjo Parnanen Nilminie Rathnayake Gunnar Johannsen Anna-Maria Heikkinen Richard Lazzara Peter van der Schoor Jan Gerrit van der Schoor Taina Tervahartiala Dirk Gieselmann Timo Sorsa |
| spellingShingle |
Saeed Alassiri Pirjo Parnanen Nilminie Rathnayake Gunnar Johannsen Anna-Maria Heikkinen Richard Lazzara Peter van der Schoor Jan Gerrit van der Schoor Taina Tervahartiala Dirk Gieselmann Timo Sorsa The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases Disease Markers |
| author_facet |
Saeed Alassiri Pirjo Parnanen Nilminie Rathnayake Gunnar Johannsen Anna-Maria Heikkinen Richard Lazzara Peter van der Schoor Jan Gerrit van der Schoor Taina Tervahartiala Dirk Gieselmann Timo Sorsa |
| author_sort |
Saeed Alassiri |
| title |
The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases |
| title_short |
The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases |
| title_full |
The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases |
| title_fullStr |
The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases |
| title_full_unstemmed |
The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases |
| title_sort |
ability of quantitative, specific, and sensitive point-of-care/chair-side oral fluid immunotests for ammp-8 to detect periodontal and peri-implant diseases |
| publisher |
Hindawi Limited |
| series |
Disease Markers |
| issn |
0278-0240 1875-8630 |
| publishDate |
2018-01-01 |
| description |
The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth rinse, gingival crevicular fluid (GCF), and peri-implantitis fluid (PISF)) is demanding. Several hosts and microbial factors may influence their expression, release, and levels. The type of saliva/oral fluids utilized for the diagnostics affects the analysis. High sensitivity and specificities together with sophisticated methods and techniques are essential for valuable outcome. We describe here recently developed practical, convenient, inexpensive, noninvasive, and quantitative mouth rinse and PISF/GCF/chair-side/point-of-care (PoC) lateral-flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyser) to detect, predict, and monitor successfully the course, treatment, and prevention of periodontitis and peri-implantitis, respectively. The tests have been independently and successfully validated to differentiate periodontal and peri-implant health and disease in Finland, Germany, Netherland, Sweden, Turkey, Nigeria, Malawi, and USA. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires additional studies utilizing these noninvasive screening, diagnostic, and preventive aMMP-8 PoC/chair-side technologies. |
| url |
http://dx.doi.org/10.1155/2018/1306396 |
| work_keys_str_mv |
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