Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate

Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate

<p>Abstract</p> <p>Background</p> <p>Cancer gene therapy by retroviral vectors is mainly limited by the level of transduction. Retroviral gene transfer requires target cell division. Cell synchronization, obtained by drugs inducing a reversible inhibition of DNA synthes...

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Bibliographic Details
Main Authors:	Nordlinger Bernard, Penna Christophe, Goere Diane, Noullet Severine, Capron Claude, Kraemer Aurore, Finzi Laetitia, Legagneux Josette, Emile Jean-Fançois, Malafosse Robert
Format:	Article
Language:	English
Published:	BMC 2011-10-01
Series:	Journal of Experimental & Clinical Cancer Research
Online Access:	http://www.jeccr.com/content/30/1/92

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