4,4'-Diisothiocyanostilbene-2,2'-disulfonic Acid (DIDS) Ameliorates Ischemia-Hypoxia-Induced White Matter Damage in Neonatal Rats through Inhibition of the Voltage-Gated Chloride Channel ClC-2

4,4'-Diisothiocyanostilbene-2,2'-disulfonic Acid (DIDS) Ameliorates Ischemia-Hypoxia-Induced White Matter Damage in Neonatal Rats through Inhibition of the Voltage-Gated Chloride Channel ClC-2

Chronic cerebral hypoperfusion is believed to cause white matter lesions (WMLs), leading to cognitive impairment. Previous studies have shown that inflammation and apoptosis of oligodendrocytes (OLs) are involved in the pathogenesis of WMLs, but effective treatments have not been studied. In this st...

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Bibliographic Details
Main Authors: Baixiong Zhao, Hongyu Quan, Teng Ma, Yanping Tian, Qiyan Cai, Hongli Li
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:International Journal of Molecular Sciences
Subjects:
DIDS
ischemia-hypoxia
Cl− channel
oligodendrocyte
blocker
apoptosis
Online Access:http://www.mdpi.com/1422-0067/16/5/10457

Internet

http://www.mdpi.com/1422-0067/16/5/10457

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