Running rescues a fear-based contextual discrimination deficit in aged mice

Normal aging and exercise exert extensive, often opposing, effects on the dentate gyrus (DG) of the hippocampus altering volume, synaptic function, and behaviors. The DG is especially important for behaviors requiring pattern separation—a cognitive process that enables animals to differentiate betwe...

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Bibliographic Details
Main Authors: Melody V. Wu, Victor M. Luna, Rene eHen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Systems Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00114/full