Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways

Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways

Background and purpose: Fengshi Gutong capsule (FSGTC), a traditional herbal formula, has been used clinically in China for the treatment of arthritis. However, the mechanism underlying the therapeutic effects of FSGTC on osteoarthritis (OA) has not been elucidated. The present study investigated th...

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Bibliographic Details
Main Authors: Yao-Xin Gao, Hao-Heng Yu, Chuan He, Ming Li, Dan-Dan Guo, Jun-Jiang Lian, Hai-Jie Yang, Mian Wang, Lei Wang, Zhi-Wei Feng, Bin-Feng Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
Fengshi Gutong capsule
osteoarthritis
rat OA model
synovial cells
pathways
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00910/full

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